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KMID : 0380420110350040284
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Journal of Prventive Veterinary Medicine
2011 Volume.35 No. 4 p.284 ~ p.290
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Effects of 3,3`, 4,4`, 5-pentachlorobiphenyl (PCB 126) on morphological changes in the developing rat testis
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Won Chung-Kil
Kim Mun-Ki
Park Oh-Sung
Park Hyeon-Soo
Choi Wan-Suk
Kim Gon-Sup
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Abstract
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This study was conducted to examine the effect of 3,3’,4,4’,5-pentachlorobiphenyl (PCB 126) on morphological changes in the developing rat testis. PCB 126 (0.2㎎/㎏/week) in corn oil was weekly i.p. injected into rats from 1 to 11 weeks old. The total body weights and testicular weights were measured at 3, 6, 9 and 12 weeks, respectively. The morphological changes in the rat testes were then analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results demonstrated that PCB 126 treatment caused significant change in the ratio of testicular weight/body weight at 9 week. The treatment of PCB increased the number of pregonium cells at 3 week and it decreased spermatogenesis of the seminiferous tubules at 6 week. The results of this study suggest that PCB 126 can damage the male reproductive organ of the growing rat and that it might be associated with retardation of development of the testis.
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KEYWORD
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Pentachlorobiphenyl, Rat, Spermatogenesis, Testis
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